Endocrine Abstracts

Introduction: Assessing cortisol status is a key endocrine investigation, to identify those who need glucocorticoid replacement or emergency sickness cover either due to primary or secondary cortisol deficiency or after long-term/high dose steroid treatment causing Hypothalamic-Pituitary-Adrenal axis (HPAA) suppression. A short synacthen test (SST) measuring cortisol levels after administration of Synthetic ACTH at time zero, 30 and 60 minutes is commonly used. A normal respon...

Objective: The aim was to investigate awakening salivary cortisol response (ACR) and its subsequent rise in normal prepubertal children and prepubertal survivors of leukaemia.Methods: 90 patients fulfilling the criteria of >1 year post treatment for leukaemia, >6 months off steroids, prepubertal, 5–12 years and in remission were recruited. Group1 Bone Marrow Transplantation (BMT) had Total Body Irradiation (n=26), Group2 Chemotherapy ...